EcoSP (E.coli Surface Polysaccharide) database is an integrated repository of bacterial O-antigens and K-antigens (Escherichia coli) , which collects comprehensive information, including serotypes, and coding region sequences,glycosyltransferases, structures and biosynthetic pathways of K-/O- antigens.


There are the lists of all published O-antigens or K antigens, displaying information including the related E. coli strains, the structure (the SPNG, chemical representation with related glycosyltransferases and CSDB test formats) and the synthesis gene cluster of each antigen.


Advanced search provides the queries: the E. coli strain (strain name or genbank accession number), and the serotype.


You can search the sugars, glycosidic bonds or the glycosyltransferases for more information, such as the related accepter sugars, the donor sugars, the glycosidic bonds and the enzymes.


There are all published syntheses pathway of the sugars in the structure of antigens, and all the pathway information including O serotypes, the related strains the key genes in sugar synthesis and the steps of synthesis by searching the sugars.


The E. coli genome sequence can be submitted for serotype prediction and glycosyltransferases annotation, and the bacterial sequence can be submitted for just glycosyl transferase prediction.

Update logs

[2022-11-01]      Modify the home page and add the flow chart and map.

[2022-03-05]      Adjust the style structure of the pathway and analysis pages

[2021-09-08]      Release all pages of this website.

[2021-08-09]      Modify the analysis programs and display style of analysis results.

[2021-06-08]      Release and modify the pathway page , modify the table style.

[2021-05-05]     Modify the content displayed in search results page.

[2021-04-23]     Release the website for the first time.

Dong, A., Liu, C., Hua, X. et al. Bioinformatic analysis of structures and encoding genes of Escherichia coli surface polysaccharides sheds light on the heterologous biosynthesis of glycans. BMC Genomics 24, 168 (2023).