LOCUS       AB811598               26523 bp    DNA     linear   BCT 13-MAY-2015
DEFINITION  Escherichia coli DNA, O-antigen biosynthetic locus, strain:
            93404-41.
ACCESSION   AB811598
VERSION     AB811598.1
KEYWORDS    .
SOURCE      Escherichia coli
  ORGANISM  Escherichia coli
            Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
            Enterobacteriaceae; Escherichia.
REFERENCE   1
  AUTHORS   Iguchi,A., Iyoda,S., Kikuchi,T., Ogura,Y., Katsura,K., Ohnishi,M.,
            Hayashi,T. and Thomson,N.R.
  TITLE     A complete view of the genetic diversity of the Escherichia coli
            O-antigen biosynthesis gene cluster
  JOURNAL   DNA Res. 22 (1), 101-107 (2015)
   PUBMED   25428893
  REMARK    DOI:10.1093/dnares/dsu043
REFERENCE   2  (bases 1 to 26523)
  AUTHORS   Iguchi,A., Iyoda,S. and Ohnishi,M.
  TITLE     Direct Submission
  JOURNAL   Submitted (29-MAR-2013) Contact:Atsushi Iguchi University of
            Miyazaki, Faculty of Agriculture; Gakuen-kibanadai-nishi 1-1,
            Miyazaki, Miyazaki 889-2192, Japan
FEATURES             Location/Qualifiers
     source          1..26523
                     /organism="Escherichia coli"
                     /mol_type="genomic DNA"
                     /strain="93404-41"
                     /db_xref="taxon:562"
                     /note="serogroup:O8"
     gene            <1..953
                     /gene="gne"
     CDS             <1..953
                     /gene="gne"
                     /note="O008_01"
                     /codon_start=3
                     /transl_table=11
                     /protein_id="BAQ00593.1"
                     /translation="TRLLETAIADFNIKNLDKQQSHFYPEITQIGDVRDQQALDQALA
                     GFDTVVLLAAEHRDDVSPTSLYYDVNVQGTRNVLAAMEKNGVKNIIFTSSVAVYGLNK
                     HNPDENHPHDPFNHYGKSKWQAEEVLREWYNKAPTERSLTIIRPTVIFGERNRGNVYN
                     LLKQIAGGKFMMVGAGTNYKSMAYVGNIVEFIKYKLKNVAAGYEVYNYVDKPDLNMNQ
                     LVAEVEQSLNKKIPSMHLPYPLGMLGGYCFDILSKITGKKYAVSSVRVKKFCATTQFD
                     ATKVHSSGFVAPYTLSQGLDRTLQYEFVHAKKDDITFVSE"
     gene            1196..2089
                     /gene="galF"
     CDS             1196..2089
                     /gene="galF"
                     /note="O008_02"
                     /codon_start=1
                     /transl_table=11
                     /product="UTP-glucose-1-phosphate uridylyltransferase"
                     /protein_id="BAQ00594.1"
                     /translation="MTNLKAVIPVAGLGMHMLPATKAIPKEMLPIVDKPMIQYIVDEI
                     VAAGIKEILLVTHASKNAVENHFDTSYELESLLEQRVKRQLLAEVQSICPPGVTIMNV
                     RQGEPLGLGHSILCARPAIGDNPFVVVLPDVVIDDASADPLRYNLAAMIARFNETGRS
                     QVLAKRMPGDLSEYSVIQTKEPLDREGKVSRIVEFIEKPDQPQTLDSDIMAVGRYVLS
                     ADIWPELERTQPGAWGRIQLTDAIAELAKKQSVDAMLMTGDSYDCGKKMGYMQAFVKY
                     GLRNLKEGAKFRKGIEKLLNE"
     gene            2281..3531
                     /gene="wzx"
     CDS             2281..3531
                     /gene="wzx"
                     /note="O008_03"
                     /codon_start=1
                     /transl_table=11
                     /product="O-antigen flippase"
                     /protein_id="BAQ00595.1"
                     /translation="MLRNILYLFGMQGTNYLLPLIILPYLVRVLGPEQYGRLGFSVAI
                     IQYLILLIDFGFNLLSSARIAKNKENAFIVSKIYSATIFAKVCISIIIIFITILLTFF
                     VPKLYDIRWLLAVSVIQIWGAIFTPIWFFQGMEVMKKFAIITVIARFISLPLIFVFVK
                     KPSDVLIAAFLQSCVFAISGVIAFILIRQMGVRLVKIKLSTISSYLKRSSGIFVGTVA
                     ISLYTLSTAVILGLVASNYDVGIFNAADKIRAALLGVFVMLGSVFYPRINNLWKFNRN
                     GAYDILRKIIIFQSLASLLLMVLFYFSVPLIVRYYLGEQYYDCIRLLKVMAPMIFLVP
                     ASIIMSNYILLPFGYRKYFSYIPVITAFMHFFYAFYLSKNYGAYGACIAILLTELISF
                     MILLVVNLKLHTFKYIFGFEYEPR"
     CDS             3506..4462
                     /note="O008_04"
                     /codon_start=1
                     /transl_table=11
                     /product="putative glycosyltransferase"
                     /protein_id="BAQ00596.1"
                     /translation="MGLNMNRDKVTVLLPVYNCESYVDECIKSIRDQTYKNLEILIIN
                     DGSNDGSEHIILKHAKQDERIIYIHQPNRGLIETLNYGLDIATGKYIARIDADDVCLP
                     NRIESQYLHMEATKADICGGNYYEINDSGDIIRKRFVPFDRVCMELSLVSRVPFAHPT
                     VMFRNSFLIENNVRYRKNANVYAEDLELWCRLKNLGASFSNTKDFLIKYRVLNTSLSR
                     LNKQKIFFDSMRFTTEYYIKHHEYLLGLLLNEGMAASLNPEEEEIVLSFIYKEILFKH
                     NLSVLYLLRKFKFKQAIKSLLRELKHYKYRKVIIGVTSESIL"
     gene            4446..5696
                     /gene="wzy"
     CDS             4446..5696
                     /gene="wzy"
                     /note="O008_05"
                     /codon_start=1
                     /transl_table=11
                     /product="O-antigen polymerase"
                     /protein_id="BAQ00597.1"
                     /translation="MKASYDSKIYFPKVLLILFFLYNVNYKFIPGDIPTSYLSLGFIV
                     VASLYWILRKKRFPVANGWALVSALLLFFCSMISYFDNIEHADLYMIRTTFIYLIMVL
                     FVSPFIACIFKNDRKEVLKTVGYAGLVNGILILGMLIFKPLQYIYLPLLSEKTFLLIG
                     GNDAIESLMSLRMIGITGFSAYTTGFVQVLCAICYIYYMILRDGRIRLKLSDYILLII
                     IFLSALVSARSSLIGIFLSIIILMFNMNSLRFIKTLSLSIISVIFLFSIITMLLPDNL
                     SDFFINWATEFFVSGTKTGSLQTNIDMYIYGLNDFSAFGQSRWYGDNNDYFMNTDVGW
                     YRLAFSIGFLGVIFWYITLMNIFRFNRLFTSRISIENIISICIFIYITIMMFKGAIIF
                     DSFQSVLILLVLDIVFYNRNKYEA"
     CDS             6135..7307
                     /note="O008_06"
                     /codon_start=1
                     /transl_table=11
                     /product="putative glycosyltransferase"
                     /protein_id="BAQ00598.1"
                     /translation="MNIGLYCNWKVKPHKNGGFYIPSVHAKYILVFKKIYKKIFLLSN
                     VGSDEINDSDVLIVDDDIHLIELPGFKNYLSALRFSKQIINGINELTEQCKYIYVRTP
                     EPLCWFFMFAKNKDKIIINHHFTSNPLDVLLKQKSFFSLKKYIKYIAFLPEYYLSIIS
                     ACVNNATCNGPSVLKNIPFFLRKRIRILIENTLTKEELVEKEYCERTHAGCYNFICVS
                     RLQEGKGLQELISAFSAFLNKHIDIDAHLTIIGDGPLKKCLEVQVATLSVSNRITIQG
                     YVQNGEPLNEFYRNAHFLINPSLSETGPRVILEAMSEGCVCLSTDVGYVRYILSQEPV
                     FDSLIIRSDFERQFCLIAKELCVNKELYTELSMKSFFIAQKYSLDSFVENIFIGQE"
     CDS             7311..8063
                     /note="O008_07"
                     /codon_start=1
                     /transl_table=11
                     /product="putative glycosyltransferase"
                     /protein_id="BAQ00599.1"
                     /translation="MHLVSIIMPTYNSSSTIHQSIESVISQTYTNWELLITDDCSSDD
                     TYKIICNYALKDHRIRVFQNNINSGAGLTRNNSIEHARGRFIAFLDSDDMWTNDKLEK
                     QIKFMLDNHFPLTYTYYKKTNASGEITGRLRPPLEVNYNELLKSNVIGCLTAIYDASS
                     LGKVYMPTIRKRQDMGLWLNILKIVPTAHCLAEELAIYREGHESLSSNKLKILRTQWL
                     FYREHVGLSFIKTLWYFSHYVIRALKKHKLPS"
     gene            8185..9591
                     /gene="gnd"
     CDS             8185..9591
                     /gene="gnd"
                     /note="O008_08"
                     /codon_start=1
                     /transl_table=11
                     /product="6-phosphogluconate dehydrogenase"
                     /protein_id="BAQ00600.1"
                     /translation="MSKQQIGVVGMAVMGRNLALNIESRGYTVSIFNRSREKTEEVIA
                     ENPGKKLVPYYTVKEFVESLETPRRILLMVKAGAGTDAAIDSLKPYLDKGDIIIDGGN
                     TFFQDTIRRNRELSAEGFNFIGTGVSGGEEGALKGPSIMPGGQKEAYELVAPILTKIA
                     AVAEDGEPCVTYIGADGAGHYVKMVHNGIEYGDMQLIAEAYSLLKGGLNLTNEELAQT
                     FTEWNNGELSSYLIDITKDIFTKKDEDGNYLVDVILDEAANKGTGKWTSQSALDLGEP
                     LSLITESVFARYISSLKDQRVAASKVLSGPQAQPAGDKAEFIEKVRRALYLGKIVSYA
                     QGFSQLRAASEEYNWDLNYGEIAKIFRAGCIIRAQFLQKITDAYAENPQIANLLLAPY
                     FKQIADDYQQALRDVVAYAVQNGIPVPTFAAAVAYYDSYRAAVLPANLIQAQRDYFGA
                     HTYKRIDKEGVFHTEWLD"
     gene            9840..11006
                     /gene="ugd"
     CDS             9840..11006
                     /gene="ugd"
                     /note="O008_09"
                     /codon_start=1
                     /transl_table=11
                     /product="UDP-glucose 6-dehydrogenase"
                     /protein_id="BAQ00601.1"
                     /translation="MKITISGTGYVGLSNGILIAQNHEVVALDIVQAKVDMLNKKQSP
                     IVDKEIEEYLATKDLNFRATIDKYDAYKNADYVIIATPTDYDPKTNYFNTSSVEAVIR
                     DVTEINPNAVMVIKSTIPVGFTKSIKERLGIDNLIFSPEFLREGKALYDNLHPSRIVI
                     GERSERAERFAALLQEGAIKQNIPTLFTDSTEAEAIKLFANTYLAMRVAYFNELDSYA
                     ESLGLNTRQIIEGVCLDPRIGNHYNNPSFGYGGYCLPKDTKQLLANYQSVPNNLISAI
                     VDANRTRKDFIADAILSRKPQVVGIYRLIMKSGSDNFRASSIQGIMKRIKAKGVEVII
                     YEPVMKEDSFFNSRLERDLATFKQQADVIISNRMAEELKDVADKVYTRDLFGSD"
     gene            11149..12129
                     /gene="wzz"
     CDS             11149..12129
                     /gene="wzz"
                     /note="O008_10"
                     /codon_start=1
                     /transl_table=11
                     /product="O-antigen chain length determinant protein"
                     /protein_id="BAQ00602.1"
                     /translation="MMRVENNNVSGQNLDPEQIDLIDLLVQLWRGKMTIIISVIVAIA
                     LAIGYLVVAKEKWTSTAIVTQPDVGQIAGYNNAINVIYGSAAPKVSEIQSILIGRFST
                     TFSALAETLDNQEEPEKLTIEPTVKNQSLPLAVSYVGQSPEAAQKQLAQYIQQVDDQV
                     NDELEKDLKDNIALRMKNLQDSLKTQEVVAQEQKELRIRQIQEALQYANQAQVTKPQI
                     QQTQDVTQDTMFLLGSDALESMVKHEASRPLVFSSTYYQTRQNLLDIERLKVDDLDIH
                     AYRYVMKPTLPIRRDSPKKAITLILAVLLGGMVGAGIVLGRNALRNYNAK"
     gene            13271..14686
                     /gene="manC"
     CDS             13271..14686
                     /gene="manC"
                     /note="O008_11"
                     /codon_start=1
                     /transl_table=11
                     /product="mannose-1-phosphate guanylyltransferase"
                     /protein_id="BAQ00603.1"
                     /translation="MLLPVIMAGGTGSRLWPMSRELYPKQFLRLFGQNSMLQETITRL
                     SGLEIHEPMVICNEEHRFLVAEQLRQLNKLSNNIILEPVGRNTAPAIALAALQATRYG
                     DDPLMLVLAADHIINNQPAFHDAIRVAEQYADEGHLVTFGIVPNAPETGYGYIQRGVA
                     LSNSAHSAYQVARFVEKPDRERAEAYLSSGEYYWNSGMFMFRAKKYLIELAKYRPDIL
                     ETCQAAVNAADNGSDFINIPHDIFCECPDESVDYAVMEKTADAVVVGLDADWSDVGSW
                     SALWEVSPKDEQGNVLSGDAWVHNSENCYINSDEKLVAAIGVENLVIVSTKDAVLVMN
                     RERSQDVKKAVEFLKQNQRSEYKRHREIYRPWGRCDVVVQTPRFNVNRITVKPGGAFS
                     MQMHHHRAEHWVILAGTGQVTVNGKQFLLSENQSTFIPIGAEHCLENPGCIPLEVLEI
                     QSGAYLGEDDIIRIKDQYGRC"
     gene            14710..16086
                     /gene="manB"
     CDS             14710..16086
                     /gene="manB"
                     /note="O008_12"
                     /codon_start=1
                     /transl_table=11
                     /product="phosphomannomutase"
                     /protein_id="BAQ00604.1"
                     /translation="MTQLTCFKAYDIRGELGEELNEDIAYRIGRAYGEFLKPGKIVVG
                     GDVRLTSESLKLALARGLMDAGTDVLDIGLSGTEEIYFATFHLGVDGGIEVTASHNPM
                     NYNGMKLVRENAKPISGDTGLRDIQRLAEENQFPPVDPARRGTLSKISVLKEYVDHLM
                     SYVYFSNFTRPLKLVVNSGNGAAGHVIDEVEKRFAAAGVPVTFIKVHHQPDGHFPNGI
                     PNPLLPECRQDTADAVREHQADMGIAFDGDFDRCFLFDDEASFIEGYYIVGLLAEAFL
                     QKQPGAKIIHDPRLTWNTVDIVTRNGGQPVMSKTGHAFIKERMRQEDAIYGGEMSAHH
                     YFRDFAYCDSGMIPWLLVAELLCLKNSSLKSLVADRQKAFPASGEINRKLSNAAEAIA
                     RIRAQYEPAAAHIDTTDGISIEYPEWRFNLRTSNTEPVVRLNVESRADVALMNEKTTE
                     LLHLLCGE"
     gene            16088..16882
                     /gene="wzm"
     CDS             16088..16882
                     /gene="wzm"
                     /note="O008_13"
                     /codon_start=1
                     /transl_table=11
                     /product="O-antigen ABC transporter permease"
                     /protein_id="BAQ00605.1"
                     /translation="MRDLLTTIYRYRGFIWSSVKRDFQARYQTSMLGALWLVLQPLSM
                     ILVYTLVFSEVMKARMPDNTGSFAYSIYLCSGVLTWGLFTEMLDKGQSVFINNANLIK
                     KLSFPKICLPIIVTLSAVLNFAIIFSLFLIFIIVTGNFPGWLFLSVIPVLLLQILFAG
                     GLGMILGVMNVFFRDVGQLVGVALQFWFWFTPIVYVLNSLPAWAKNLMMYNPMTRIMQ
                     SYQSIFAYHLAPNWYSLWPVLALAIIFCVIGFRMFRKHAADMVDEL"
     gene            16882..18096
                     /gene="wzt"
     CDS             16882..18096
                     /gene="wzt"
                     /note="O008_14"
                     /codon_start=1
                     /transl_table=11
                     /product="O-antigen export system, ATP-binding protein"
                     /protein_id="BAQ00606.1"
                     /translation="MSYIRVNNVGKAYRQYHSKTGRLIEWLSPLNTKRHNLKWILRDI
                     NFEVAPGEAVGIIGINGAGKSTLLKLITGTSRPTTGEIEISGRVAALLELGMGFHSDF
                     TGRQNVYMSGQLLGLSSEKITELMPQIEEFAEIGDYIDQPVRVYSSGMQVRLAFSVAT
                     AIRPDVLIIDEALSVGDAYFQHKSFERIRKFRQEGTTLLLVSHDKQAIQSICDRAILL
                     NKGQIEMEGEPEAVMDYYNALLADKQNQSIKQVEHNGKTQTVSGTGEVTISEVHLLDE
                     QGNVTEFVSVGHRVSLQVNVEVKDDIPELVVGYMIKDRLGQPIFGTNTYHLNQTLTSL
                     KKGEKRSFLFSFDARLGVGSYSVAVALHTSSTHLGKNYEWRDLAVVFNVVNTEQQEFV
                     GVSWLPPELEIS"
     CDS             18096..19373
                     /note="O008_15"
                     /codon_start=1
                     /transl_table=11
                     /product="putative methyltransferase"
                     /protein_id="BAQ00607.1"
                     /translation="MGSSFYRSFEERHRGSVEEIKRRLSFYLPFLAGLKDIYPDGVIA
                     DIGCGRGEWLEILTENGIANIGVDLDDGMLARAREAGLNVQKMDCLQFLQSQADQSLI
                     ALTGFHIAEHLPFEVLQQLVMHTLRVLKPGGLLILETPNPENVSVGTCSFYMDPTHNH
                     PLPPPLLEFLPIHYGFNRAITVRLQEKEVLQSPDAAVNLVDVLKGVSPDYSIIAQKAA
                     PTDILERFDTLFTQQYGLTLDALSNRYDAILRQQFSSVVSRLETLNQTYMQQISQMSE
                     TIQTLQGEVDDLSHVIDQNHQLHQQMADLHNSRSWRITQPLRWLSLQRQLLRQEGAKV
                     RARRAAKKILRKGMALSLVFFHRYPKSKVYLFKVLRKTGCYTLLQRLFQRVMLVQSDT
                     MMMQSRRYDVGTEEMTSRAMSIYNELKNKNTEK"
     CDS             19376..23017
                     /note="O008_16"
                     /codon_start=1
                     /transl_table=11
                     /product="putative mannosyltransferase"
                     /protein_id="BAQ00608.1"
                     /translation="MRIVIDLQGAQTESRFRGIGRYSIAIARGIIRNNSRHEIFIALS
                     AMLDESIADIKAQFADLLPAENIVVWHAVGPVRAMDQGNEWRRESAELIREAFLESLC
                     PDVVFITSLFEGHVDDAATSVHKFSRQYKVAVLHHDLIPLVQAETYLQDDVYKPYYLQ
                     KVEWLKNADLLLTNSAYTAQEAIEHLHLQGDHVQNIAAAVDSQFCMAEVTASEKETVL
                     GHYGIQREFMLYAPGGFDSRKNFKRLIEAYAGLSDALRRSHQLVIVSKLSIGDRQYLE
                     SLASGNGLQQGELVLTGYVPEDELIQLYRLCKLFIFASLHEGFGLPVLEAMSCGAPVI
                     GSNVTSIPEVIGNPEALFDPYSVSSMRDKIAQCLTDDTFLARLKEMAQQQARNFSWDK
                     AAVTALEAFEKIAVEDTGTAQVLPEALIQKILAITQGQPDDRDLRLCATAIDYNLKTA
                     ELYQIDDKSLNWRVEGPFDSSYSLALVNREFARALSADGVEVLLHSTEGPGDFAPDAS
                     FMAQSENSDLLAFYNQCQTRKSNEKIDILSRNIYPPRVTKMDAKVKFLHCYAWEETGF
                     PQPWINEFNRELDGVLCTSEHVRKILIDNGLNVPAFVVGNGCDHWLNIPAETTKDVDH
                     GTFRFLHVSSCFPRKGIQAMLQAWGKAFTRRDNVILIIKTFNNPHNEIDAWLAQAQAQ
                     FIDYPKVEVIKEDISATELKGLYESCDVLVAPGCAEGFGLPIAEAMLSGLPAIVTNWS
                     GQLDFVNSQNSWLVDYQFTRVKTHFGLFSSAWASVDIDNLTDALKAAASTDKSVLRDM
                     ANAGRELLLQQFTWKAVADRSCQAVKTLRAHIDIAQHRARIGWLTTWNTKCGIATYSQ
                     HLVESAPHGADVVFAPQVSAGDLVCADEEFVLRNWIVGKESNYLENLQPHIDALKLDV
                     IVIQFNYGFFNHRELSVFIRRQHDAGRSVVMTMHSTVDPLEKEPSWNFRLAEMKEALA
                     LCDRLLVHSIADMNRLKDLGLTANVALFPHGVINYTAASVTRQQQSLPLIASYGFCLP
                     HKGLMELVESVHRLKQAGKPVRLRLVNAEYPVGESRDLVAELKAAAQRLGVTDLIEMH
                     NDFLPDAESLRLLSEADLLIFAYQNTGESASGAVRYGMATQKPVAVTPLAIFDDLDDA
                     VFKFDGCSVDDISQGIDRILNSIREQNSWATRTQQRADAWREQHDYQAVSRRLVNMCQ
                     GLAKAKYFK"
     CDS             23069..24226
                     /note="O008_17"
                     /codon_start=1
                     /transl_table=11
                     /product="putative glycosyltransferase"
                     /protein_id="BAQ00609.1"
                     /translation="MSFIMKIIFATEPIKYPLTGIGRYSLELVKRLAVAREIEELKLF
                     HGASFIEQIPLVENKSDTKASNHGRLSAFLRRQTLLIEAYRLLHPRRQAWALRDYKDY
                     IYHGPNFYLPHKLERAVTTFHDISIFTCPEYHPKDRVRYMEKSLHESLDSAKLILTVS
                     DFSRSEIIRLFNYPAERIVTTKLACSSDYIPRSPAECLPVLQKYQLAWQAYALYIGTM
                     EPRKNIRGLLHAYQLLPMEIRMRYPLILSGYRGWEDDVLWQLVERGTREGWIRYLGYV
                     PDEDLPYLYAAARVFVYPSFYEGFGLPILEAMSCGVPVVCSNVTSLPEVVGDAGLVAD
                     PNDIDAISAQILQSLQDDSWREIATARGLAQAKQFSWENCATQTINAYKLL"
     CDS             24236..25351
                     /note="O008_18"
                     /codon_start=1
                     /transl_table=11
                     /product="putative glycosyltransferase"
                     /protein_id="BAQ00610.1"
                     /translation="MRVLHVYKTYYPDTYGGIEQVIYQLSQGCARRGIAADVFTFSPD
                     KDTGPVAYEDHRVIYNKQLFEIASTPFSLKALKRFKLIKDDYDIINYHFPFPFMDMLH
                     LSARPDARTVVTYHSDIVKQKRLMKLYQPLQERFLSGVDCIVASSPNYVASSQTLKKY
                     LDKTVVIPFGLEQQDVQHDPQRVAHWRETVGDKFFLFVGTFRYYKGLHILMDAAERSR
                     LPVVVVGGGPLESEVRREAQQRGLSNVMFTGMLNDEDKYILFQLCRGVVFPSHLRSEA
                     FGITLLEGARFARPLISCEIGTGTSFINQDKVSGCVIPPNDSQALVEAMNELWNNEET
                     SNRYGENSRRRFEEMFTADHMIDAYVNLYTTLLESKS"
     gene            complement(25390..25998)
                     /gene="hisI"
     CDS             complement(25390..25998)
                     /gene="hisI"
                     /codon_start=1
                     /transl_table=11
                     /product="phosphoribosyl-AMP cyclohydrolase"
                     /protein_id="BAQ00611.1"
                     /translation="MLTEQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDK
                     TIESGKVTFFSRTKQRLWTKGETSGNFLNVVNIAPDCDNDTLLLLANPIGPTCHKGTS
                     SCFGDTAHQWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALA
                     ATVNDRFELKNEASDLVYHLLVLLQDQGLDLGEVIDNLKNRH"
ORIGIN      
        1 gaacccgact acttgaaacg gcaattgctg actttaatat caagaacctg gacaaacagc
       61 agagccactt ttatccagaa atcacacaga ttggcgatgt tcgtgatcaa caggcactcg
      121 accaggcgtt agccggtttt gacactgttg tgctactggc agcggaacac cgcgatgacg
      181 tcagccctac ttctctctat tatgatgtca acgttcaggg tacccgcaat gtgctggcgg
      241 ccatggaaaa aaatggcgtt aaaaatatca tctttaccag ttccgttgct gtttatggtt
      301 tgaacaaaca caaccctgac gaaaaccatc cacacgatcc tttcaaccac tacggcaaaa
      361 gtaagtggca ggcagaggaa gtgctgcgtg aatggtataa caaagcacca acagaacgtt
      421 cattaactat catccgtcct accgttatct tcggtgaacg caaccgcggt aacgtctata
      481 acttgctgaa acagatcgct ggcggcaagt ttatgatggt gggtgcagga actaactata
      541 agtccatggc ttatgttgga aacattgttg agtttatcaa gtacaaactg aagaatgttg
      601 ccgcaggtta tgaggtttat aactacgttg ataagccaga tctgaacatg aaccagttgg
      661 ttgcggaagt tgaacaaagc ctgaacaaaa agatcccttc tatgcacttg ccttacccac
      721 taggaatgct gggtggatat tgctttgata tcctgagcaa aattacgggc aaaaaatacg
      781 cagtcagctc tgtgcgcgtg aaaaaattct gcgcaacaac acagtttgac gcaacgaaag
      841 tgcattcttc aggttttgtg gcaccgtata cgctgtcgca aggtctggat cgaactctgc
      901 agtatgaatt cgttcatgcc aaaaaagacg acataacgtt tgtttctgag taatgcagac
      961 gagtcagaga aaaaaggacc aggttggact acgattattc ggaaagaggt actgattaaa
     1021 ttatcagtat gcggaattcc gagtaatccg agtaacccag atgctgatgg tgtgtagtgt
     1081 tatcgtaagg tttaatcaaa gttatgcgga actaagcttt ggtatatagc cataacgttt
     1141 ggctaaccta tggcaataat ttacgcacta tcagccactt agaggtagga aaagaatgac
     1201 gaatttaaaa gcagttatac cggtagcagg tcttgggatg catatgttgc ctgccactaa
     1261 ggcgattccc aaagagatgc taccgatcgt cgacaagcca atgattcagt acattgttga
     1321 cgagattgtg gctgcaggga tcaaagaaat cctcctggta actcacgcgt ccaagaacgc
     1381 ggtcgaaaac cacttcgaca cctcttatga attagaatct ctccttgaac agcgcgtgaa
     1441 gcgtcaactg ctggcggaag tacaatctat ctgtccgccg ggcgtgacca ttatgaacgt
     1501 gcgtcagggt gaacctttag gtttgggcca ctccattttg tgtgcacgcc ccgccattgg
     1561 cgacaaccca tttgtcgtgg tgctgccgga cgttgttatc gatgatgcca gcgccgaccc
     1621 gctgcgctac aaccttgctg ctatgattgc gcgcttcaat gaaacgggcc gtagtcaagt
     1681 gctggcaaaa cgtatgccgg gtgacctctc tgaatactcc gtcatccaga ccaaagaacc
     1741 gctggaccgt gaaggcaaag tcagccgcat tgttgaattt atcgaaaaac cggatcagcc
     1801 gcagacgctg gactcagaca tcatggccgt aggtcgttat gtgctttctg ccgatatttg
     1861 gccggaactt gaacgcactc aacctggtgc atgggggcgt attcagctga ctgatgccat
     1921 tgctgaactg gcgaaaaaac agtccgttga tgcaatgctg atgactggtg acagctacga
     1981 ctgcggtaaa aaaatgggtt atatgcaggc gtttgtgaag tatggcttac gcaacctgaa
     2041 agaaggggcg aagttccgta aagggattga gaagctactg aatgaataat ttgaagcctg
     2101 aatgattctg aggaaaatgg tgattatttt aatcaccact gattttacaa taggttagta
     2161 tatgttccta aaatttaact ctttgagctc tttggttgct atagtcaagg cggtagcgtg
     2221 cattataaat aatcctagag cttatattta atatttaggt aagagcattg gaacaatgaa
     2281 atgttaagga atattcttta tctttttgga atgcagggaa ccaattattt actgccgcta
     2341 ataatacttc cttatttagt acgtgttctt ggaccagagc agtacgggcg attaggattt
     2401 tcagttgcca taatacagta tttgatattg ttaatcgact ttgggtttaa tttactgtcg
     2461 tcagccagaa tagcaaagaa taaagagaat gcatttatcg taagtaaaat atattctgcg
     2521 actatctttg ccaaagtgtg tatatcaata attataatct ttattactat acttctgaca
     2581 ttttttgtcc ctaaattata tgatatacgt tggttgttgg ctgtttcggt tattcaaata
     2641 tggggggcaa tatttacgcc aatttggttt tttcagggga tggaagtgat gaagaaattt
     2701 gctattatta ctgttatagc aaggtttatt tcattaccgc ttattttcgt ttttgtcaag
     2761 aaaccaagtg atgttttaat agccgctttt cttcagtcgt gcgtctttgc tatatctgga
     2821 gtgattgcgt ttattttaat tagacagatg ggagttagac tagttaaaat taaattgtcg
     2881 actatttcca gttatctcaa aagaagtagt ggcatttttg tcggaactgt agctataagt
     2941 ctatatactc tcagtactgc tgtaatttta ggccttgttg catcaaatta tgatgtaggt
     3001 atttttaatg cagcagataa aattagagca gcattacttg gtgtgtttgt aatgttaggt
     3061 agtgtttttt atccaaggat taataatcta tggaagttca acagaaatgg ggcatatgat
     3121 attttaagga aaatcataat atttcagtca ttagcatcat tactgcttat ggttttgttt
     3181 tatttttcag ttccacttat agttcgttat tatttaggtg agcaatatta tgattgtatt
     3241 agattgttaa aagtcatggc gcctatgatt ttccttgttc cagcctctat aataatgtct
     3301 aactatattt tattgccttt tggatatagg aaatatttta gttacattcc agttattact
     3361 gcctttatgc atttctttta tgcattttat ttgtcaaaaa attatggggc ctatggcgca
     3421 tgtattgcaa tattattaac ggaattaatt agctttatga ttttacttgt agttaattta
     3481 aaattgcata ccttcaaata tatatttggg tttgaatatg aaccgagata aagttacagt
     3541 cttattgcca gtgtataatt gtgaatctta tgttgatgag tgtattaaat ctattcgcga
     3601 tcaaacatat aaaaaccttg agatattaat aattaatgat ggttcaaatg atggttcaga
     3661 acatattata cttaaacacg ctaagcaaga tgaacggatt atatatattc accagccaaa
     3721 tcgagggttg attgaaacat taaattatgg cttagatata gccactggaa aatatattgc
     3781 ccggatcgat gctgatgacg tctgtttgcc caacagaatt gaaagtcaat atttacatat
     3841 ggaggcgacg aaagcagata tatgtggagg aaattactac gagataaatg attcaggtga
     3901 tattatccgc aagcgttttg ttccttttga tagagtttgt atggaactct ctctggtaag
     3961 cagagttcca tttgcacatc cgacagtcat gtttagaaat agcttcttga tagagaataa
     4021 tgttcgctat aggaagaatg caaatgtata tgcagaagat ttagagttat ggtgtagatt
     4081 aaaaaatttg ggagcatcat tttctaatac gaaagacttt ttaataaaat atagagtgtt
     4141 aaatacttcg ctttctcgct tgaataagca aaaaatattt tttgattcaa tgaggtttac
     4201 gactgaatat tatattaagc accatgagta tttgctgggt ttgctattaa atgaagggat
     4261 ggcagcttca ttaaatccag aggaagaaga aatagttctt tcatttattt ataaggagat
     4321 tctttttaag cataatttat ctgttttata tcttcttagg aaatttaaat ttaaacaagc
     4381 aatcaaatct ttattacgtg aattgaaaca ttacaaatac cgcaaagtaa ttataggtgt
     4441 aacaagtgaa agcatcttat gattcaaaga tatattttcc taaagtttta ttaattctgt
     4501 tttttttgta taatgtgaat tataaattta taccaggcga catacctaca agctatttaa
     4561 gtttaggttt tattgtagta gcttctttat actggatact taggaaaaaa aggttccctg
     4621 ttgccaatgg ttgggcgctt gttagcgcat tacttttatt tttttgttca atgattagct
     4681 attttgataa tatagaacat gctgatttat acatgattag aacaacattt atctatctta
     4741 ttatggtgct gtttgtatcg ccatttattg cttgtatatt taaaaatgac cgaaaggaag
     4801 tattaaaaac ggtagggtat gcagggttgg taaatggtat tttgatactg ggtatgctta
     4861 tatttaagcc attgcaatat atatatttac ctctgttaag tgaaaaaacg ttcttgctaa
     4921 tcggaggaaa tgatgcaatt gaaagtttga tgtctttacg tatgattggc atcacggggt
     4981 tttctgcgta tacaaccggt tttgtccagg tgttatgtgc aatttgttat atatattata
     5041 tgatactcag agatggacga ataaggctaa aattgtctga ttatatcttg ttgattatta
     5101 tttttttatc ggcattggtt tctgcacgtt cgtctctgat tggtattttt ctgtcgatca
     5161 taattcttat gtttaatatg aattcattaa gatttataaa aacattatca ttatcaatta
     5221 tcagtgttat ttttttattt agcattataa ctatgttgtt gccagataat ctgagtgatt
     5281 ttttcattaa ttgggctact gaattttttg tttctggtac caaaactggc tcattacaaa
     5341 ctaatattga tatgtacatc tacggtttga atgattttag tgcgtttggt caatccaggt
     5401 ggtatggtga taataatgat tattttatga acacagatgt tggatggtat aggcttgcat
     5461 tttcaattgg ttttttgggc gtaattttct ggtatataac actaatgaat atttttagat
     5521 tcaacaggtt gtttacatct agaatttcta ttgaaaatat aatttcaatt tgtatattta
     5581 tatacattac tataatgatg ttcaaagggg cgattatatt tgatagtttt caatctgtct
     5641 tgattttatt ggttttagat attgtatttt acaacaggaa taaatatgaa gcataagttt
     5701 ttattaatgt attcattttt tgtaaggtta atatttttat ggttgccaga taccccgatg
     5761 ataatgcgat ttcggggtta tgtttactca tggggcatga ataaatgtgg gcataatctc
     5821 caagtttcat ctactgcagt gctacgtgga atcgaacgga tatcctgtgg gaatgatgta
     5881 tattttggtc ccaattcata tattatggca cgtaaatcaa taataattgg tgatgaaaca
     5941 ttagttgcta tgaatgtcgt gattgtcgat gctaatcatg gtaaagaaaa taatagttat
     6001 agatttaaaa ggggaagtgc aaaggagatt aatatagggc gaggggtatg gattgcagca
     6061 aactgtgttg ttactgcagg ttcaactata aaagatggta cattaattcc accttgttca
     6121 gtggttaggt aattatgaat attggattat attgtaattg gaaagttaaa ccgcataaga
     6181 atggtgggtt ttatatacct agtgttcatg ctaaatatat ccttgtattt aagaaaatat
     6241 ataaaaaaat atttttactg tcaaatgttg gtagtgatga aataaatgat tctgatgttc
     6301 taattgtcga tgatgatata cacttaatag agttgcctgg tttcaaaaat tatttatcag
     6361 ctttaaggtt tagtaagcaa attattaatg gtataaatga acttaccgaa cagtgtaaat
     6421 atatatatgt aaggactcca gagcctttat gttggttttt tatgtttgcg aaaaacaaag
     6481 ataaaattat aataaatcat cattttacat ctaatccatt agatgttctt cttaaacaaa
     6541 aatcattttt ttcccttaaa aaatacataa aatatatagc gtttcttcca gagtattatc
     6601 tttcgattat ttctgcatgt gtaaataatg ccacatgtaa tggcccgtca gttctgaaaa
     6661 atatcccttt cttcttaaga aaaagaattc gaattcttat tgaaaatacg cttacaaaag
     6721 aagaattagt agaaaaagaa tattgtgaaa gaacacatgc aggctgttat aattttattt
     6781 gtgttagtcg gttacaagaa ggtaagggac ttcaagaact catctctgca ttttctgctt
     6841 tcttaaataa acatattgat attgatgctc atctaactat tattggggat ggacctttaa
     6901 agaaatgttt agaagttcaa gttgctactt tatcagtctc caatcgaatt actatacaag
     6961 gatatgtgca aaatggagaa ccacttaatg aattttatag gaatgctcat tttttaataa
     7021 atccttcttt atctgaaact ggaccgagag taattttgga ggcgatgtct gaaggatgtg
     7081 tttgcctgtc aactgatgtt ggttacgtgc gctacatctt aagccaagaa ccagtttttg
     7141 attctttaat aatacgctct gattttgaaa gacaattttg cttaattgca aaagaattat
     7201 gtgtaaataa agaattatat actgaattat cgatgaaatc cttttttatt gcacaaaaat
     7261 attcattgga ctcatttgtt gagaatatat tcatcggaca ggagtagtaa atgcatcttg
     7321 tttcaataat tatgccaaca tataattcgt catcgactat acatcagagt attgaatctg
     7381 taatttcgca aacctataca aattgggaat tgctaataac tgatgattgc tcttctgacg
     7441 atacttacaa aattatctgc aattacgcac tcaaagacca tagaattaga gtattccaga
     7501 ataacataaa ctctggtgct ggcctgacta gaaataactc tatcgaacat gctcgcggaa
     7561 gatttattgc ttttctcgat agcgatgata tgtggactaa tgataaactt gaaaaacaaa
     7621 taaaattcat gttggataat cattttcctt taacctacac ctattataaa aagactaatg
     7681 catctggaga aatcaccggc agattaaggc caccattaga agttaactat aacgaactat
     7741 taaaatctaa cgttattggt tgtttgactg caatatatga tgcttcctca ttgggcaaag
     7801 tatatatgcc tacaattcgt aaacgtcagg atatgggatt atggcttaat atcctaaaaa
     7861 tagtaccaac tgctcattgt ttggctgagg aattggctat ttatagagag gggcacgaaa
     7921 gcctttcatc gaataaatta aagatcctac gaactcaatg gttattttat agagagcatg
     7981 tcgggttgag ttttattaaa accttatggt atttttcaca ctatgttatt agagcattaa
     8041 aaaaacataa attaccaagc taactcgaaa ttgaataact ccttattgct attttgaaaa
     8101 ctagcagcat aatattaata cacatacgta gattcatttg tctataccgc attctcccgc
     8161 ggtaacccct gacaggagta aacaatgtca aagcaacaga tcggcgtcgt cggtatggca
     8221 gtgatggggc gcaaccttgc gctcaacatc gaaagccgtg gttataccgt ctctattttc
     8281 aaccgttccc gtgagaaaac ggaagaagtg attgccgaaa atccaggcaa gaaactggtt
     8341 ccttactata cggtgaaaga gtttgttgaa tctctggaaa cgcctcgtcg catcctgtta
     8401 atggtgaaag caggtgcagg cacggatgct gctattgatt ccctcaaacc atatctcgat
     8461 aaaggtgata tcatcattga tggcggtaac accttcttcc aggacaccat tcgtcgtaac
     8521 cgtgagcttt ctgccgaagg ctttaacttc attggtaccg gtgtctccgg tggtgaagaa
     8581 ggcgcgctga aaggtccttc cattatgcca ggtgggcaga aagaagccta tgaactggtt
     8641 gcaccgatcc tgaccaaaat cgccgcagtg gctgaagacg gtgagccatg cgttacctat
     8701 attggtgccg atggtgcagg tcactatgtg aagatggttc acaacggtat tgaatacggc
     8761 gatatgcagc tgattgctga agcctattct ctgcttaaag gtggcctgaa tctcaccaac
     8821 gaagagttgg cgcagacctt taccgagtgg aataacggtg aactgagcag ctacctgatc
     8881 gacattacca aagatatctt caccaaaaaa gatgaagacg gtaactacct ggttgatgtg
     8941 attctggatg aagcggctaa caaaggtacc ggtaaatgga ccagccagag tgcgctggat
     9001 ctcggcgaac cgctgtcgct gattaccgag tctgtgtttg cacgttatat ctcttctctg
     9061 aaagatcagc gtgttgccgc atctaaagtt ctctctggcc cgcaagcaca gccagcaggc
     9121 gacaaagctg agtttatcga gaaagttcgt cgtgcgctgt atctgggcaa aatcgtttct
     9181 tatgctcagg gcttctctca gctgcgtgcg gcgtctgaag agtacaactg ggatctgaac
     9241 tatggcgaaa tcgcgaagat tttccgtgct ggctgcatca tccgtgcgca gttcctgcag
     9301 aaaatcaccg atgcttatgc cgaaaatccg cagatcgcta acctgctgct ggctccgtac
     9361 ttcaagcaaa ttgccgatga ctaccagcag gcgctgcgtg atgtcgttgc ttatgcagta
     9421 cagaacggta tcccggttcc gaccttcgcc gctgcggttg cctattatga cagctaccgt
     9481 gccgcggttc tgcctgcaaa cctgatccag gcacagcgtg actatttcgg tgcacatact
     9541 tataagcgca ttgataaaga aggtgtgttc cataccgaat ggctggatta atctgattta
     9601 aatcaattaa tcaaagcaag gcccggagaa accctccggg cttttttatt atacaaagcg
     9661 gcaggttatg gccttttttt ataatttatg gttaaaaaag cgatataata cagagccgca
     9721 cagcaggatc gctgccttga cagttcatct acatcagcgt taaaaatccc gcagtagatg
     9781 aagctgtggt ggtggattaa tgaccactct aaatgtttaa ccggaagaag tcagagctaa
     9841 tgaaaataac aatttcagga acaggttatg ttggtctttc aaatggtatt ctgattgcgc
     9901 aaaaccacga agtggttgca ctggatatcg ttcaggccaa agtggacatg cttaacaaga
     9961 agcagtcacc gattgttgat aaggagattg aagagtatct ggcgactaaa gatctcaatt
    10021 tccgcgctac gatagataag tatgacgcgt ataaaaatgc cgattacgtt attattgcca
    10081 cacctaccga ttatgatccg aaaacaaatt attttaatac ctcaagcgtg gaagcggtca
    10141 ttcgcgatgt gacagaaatt aatcctaatg ctgtcatggt gattaaatct acaattccgg
    10201 taggtttcac caaatcaatt aaagaacgtc tgggtatcga taaccttatt ttctctccgg
    10261 aatttctccg tgaaggtaaa gctctttacg ataatctcca tccttcacgt attgtcatcg
    10321 gtgagcgttc agaacgcgca gaacgttttg cggcgttatt acaggaaggc gcgattaagc
    10381 aaaatatccc aaccctgttt accgattcaa ccgaagcaga agcgattaaa cttttcgcta
    10441 atacctatct ggcgatgcgc gtagcatact ttaatgaact ggatagctat gcagaaagtt
    10501 taggtctgaa tactcgccag attatcgaag gcgtttgtct cgatccgcgt attggcaacc
    10561 attacaacaa tccgtcgttt ggttatggtg gttattgtct gccgaaagat accaagcagt
    10621 tactggcgaa ctaccagtct gtgccgaata acctgatctc ggcaatcgta gacgctaacc
    10681 gcacgcgtaa agattttatt gccgatgcca ttttgtcacg caagccgcaa gtggtgggta
    10741 tttatcgtct gattatgaag agcggttcag ataacttccg tgcgtcttcc attcagggga
    10801 ttatgaaacg tatcaaggcg aaaggcgttg aagttatcat ttacgagccg gtgatgaaag
    10861 aagactcatt cttcaactct cgcctggaac gtgatctcgc gaccttcaaa caacaagccg
    10921 acgttattat ctccaaccgt atggcagaag agcttaagga tgtggcagac aaagtctaca
    10981 cacgagatct ctttggcagc gactaatctt ctctgatcag ggcggtttcg ccctgattgt
    11041 cttttgtaac ctgtgcaata attcattgtt tttatcattt atcctatagt attcactaag
    11101 attatcacta cactatgcag acctaaaatt ataacgtccg ttagggtaat gatgagagta
    11161 gaaaataata atgtttctgg gcaaaacctt gacccggaac agattgattt gattgattta
    11221 ctggtgcaac tatggcgtgg caagatgaca atcatcattt ctgtcattgt cgctattgcc
    11281 ctggcaatag gatatctggt cgttgccaaa gaaaaatgga cttccacagc tatcgttact
    11341 caacctgatg tggggcaaat cgctggttat aacaatgcca taaatgtgat ttatggttca
    11401 gccgcgccga aagtgtctga gatccagtcg attttaattg gccgcttcag cacgacattt
    11461 tctgcattag cagaaacgct tgataatcag gaagaacctg aaaaactgac cattgaacct
    11521 actgttaaaa atcagtcatt acctttagcg gtgtcttatg ttggacaatc gcctgaagct
    11581 gcgcagaaac agctggctca atatatccag caagttgacg accaggtaaa tgatgaactt
    11641 gaaaaagatc tgaaagacaa catcgcgctg cgtatgaaaa acttacagga ttctctgaag
    11701 acccaggaag tggtcgctca ggagcaaaaa gagctgcgta ttcgtcaaat tcaggaagcg
    11761 ttgcagtatg cgaatcaggc gcaggtgaca aagccgcaga ttcagcagac acaggacgtg
    11821 acccaggata ccatgttcct tttggggagt gatgcactgg agtcgatggt aaagcacgaa
    11881 gcgagccgtc cgttggtgtt ctcgtcaacc tactatcaga ctcgtcaaaa cctgctggat
    11941 atcgaaagat taaaggttga tgatcttgat attcacgctt accgctatgt gatgaaacct
    12001 acgttaccca ttcgtcgtga tagcccgaag aaggcaatca ctttgattct ggcggtgctg
    12061 ctgggcggca tggttggcgc gggtattgta ctggggcgta acgcgctgcg taattacaac
    12121 gcgaagtgat ttttgagctt aaagaaagcg ggcagggtgg tcacaccgtg cccgtttttt
    12181 ttgtcggatg cgatgccggc gtatcttatc cagcttacat atgttgagaa aatttgtagg
    12241 cacgataaac ctgcacaccg ggcaatgacg gatgagttgt tgccggaagt gacagcaaca
    12301 tcacatccgc ctaccccgca actcactgat gccgcgtgcg cagaatcact atcactgttg
    12361 ttaaatccag catttgaacc tgcaacagca ccagcaggcg atacatcaaa tcaggcacct
    12421 cattggttag tatgtacctt cgcaaaacgg gattactcac agcgaacatg gcgcaatttt
    12481 gtacaaatct gtttttttta tcagcagatt atttagcaac caggcaaaaa aatgtcatgc
    12541 ctttcttcat ttttacttat atatcaattg attataatta attggtttgg taaatgttta
    12601 agatgtgtat tatatgagta atccattaat tagtcggctt ttatattttt tttcccagca
    12661 tgcaacgcta taatctgcga agattttttt gtggaatgtg cagtgtagag gcatgagtcg
    12721 tttatcccac cagtcgcaac ataacgccgt cgtcgtgtgc aaagagctgt caagcccgaa
    12781 cgcgcgctgc ttctctggcg gcgaatacga tgtctcttct tatctttcct cgtatcgtaa
    12841 atgctccttt ctgatggttg ctggcatcgg taaatcactt gattcgtttt ttttgatggc
    12901 ggtgagagca tgtgttttgc cccgcgtaaa tgagaaggtc ctgatggtta ctctggcggc
    12961 aaatgtggaa attgtggggc gtttcgtggc ctggtgagga acagatacat attaaaagca
    13021 gagatatgcc ctgagacata tctctgcttt taggttttca ggatgcccgt tccgtaagga
    13081 tggtttttga gaccgctgag tgaaggggct gccgacagtc tgaagcgaaa gagggtggcg
    13141 tttagcctgg agcactacgc attttggttg cgatagccaa tggcggtagc gtacctgaaa
    13201 aaggccattc aacccgttgg tcgattgatt gatagtaaaa taaaacaatt atttatttaa
    13261 ggatttcatt atgttacttc ctgtaattat ggctggtggt accggcagtc gtctctggcc
    13321 gatgtcacgc gagctttatc cgaaacagtt cctccgcctg ttcgggcaga actccatgct
    13381 gcaggaaacc atcacccgac tctcgggtct tgaaatccat gaaccgatgg tcatctgtaa
    13441 cgaagagcat cgcttcctgg tggctgaaca gctgcgccag ctaaataagc tgtcgaataa
    13501 cattatactt gagccggtcg ggcgcaacac cgcgccggcc atcgccctgg cggcccttca
    13561 ggccacccgc tacggtgacg acccgctgat gctggttctc gccgccgacc acatcatcaa
    13621 taaccagccg gccttccacg acgctatccg tgttgccgag cagtatgctg atgaaggtca
    13681 tctggtcacc ttcggtatcg tgccgaatgc cccggaaact ggctacggtt acattcagcg
    13741 cggcgtggcg ctcagcaata gtgcccattc cgcgtaccag gtggcccgct ttgtggagaa
    13801 gcctgatcgc gagcgcgccg aggcttacct ctcctccggg gagtactact ggaacagcgg
    13861 catgtttatg ttccgcgcca agaaatacct catcgagctg gccaaatacc gtccggatat
    13921 cctggaaacc tgccaggctg cggtgaatgc cgccgataat ggcagcgatt tcatcaatat
    13981 cccacatgat attttctgcg agtgcccgga tgagtccgtg gactacgccg ttatggagaa
    14041 aaccgctgat gcggtggtgg tcggtctcga tgctgactgg agcgacgttg gctcctggtc
    14101 cgcactatgg gaggtcagcc cgaaagacga gcagggcaac gtccttagtg gcgacgcgtg
    14161 ggtacacaac agcgaaaact gctacatcaa cagcgacgag aagctagtgg cggccattgg
    14221 cgtagagaat ctggtgattg tcagcactaa ggacgccgtg ctggtgatga atcgcgagcg
    14281 ttcccaggac gtgaagaagg cggtcgagtt cctcaagcag aaccagcgca gcgagtacaa
    14341 gcgccaccgt gagatttacc gcccctgggg ccgctgcgac gtggtggtcc agaccccgcg
    14401 attcaacgtc aaccgtatca cggtgaaacc aggcggtgcc ttctcgatgc agatgcacca
    14461 ccatcgcgcc gagcattggg ttattctcgc cggcaccggt caggtgactg tcaacggtaa
    14521 gcagttcctg ttgtccgaga accagtccac ctttattccg attggcgccg agcactgcct
    14581 ggaaaaccct ggctgtattc cgctggaagt gctggagatc cagtcggggg cgtaccttgg
    14641 cgaggacgac attattcgta ttaaagacca gtatggtcgt tgctaattat tttcgggaca
    14701 agacgcagaa tgacacagtt aacttgtttt aaagcttatg acatccgtgg tgaactgggt
    14761 gaggaactga acgaggacat cgcctaccgt atcggtcgcg cctacggcga atttctgaaa
    14821 cccgggaaga tagtggtggg gggcgatgtg cgcctcacaa gcgagtcgct gaagctggcg
    14881 ctggcccgcg ggttaatgga cgccggtacc gacgtgctgg acatcggcct gagcggtacc
    14941 gaagagattt actttgccac cttccacctt ggggtagatg gtggcatcga ggtgaccgcg
    15001 agccacaatc ctatgaacta caacggcatg aagctggtgc gcgagaatgc gaagcccatc
    15061 agcggcgaca ccggcctgcg ggatatccag cgcctggcgg aggaaaacca gttcccgcca
    15121 gtggacccgg cgcgtcgcgg gaccctgagc aagatatcgg tactgaagga gtatgttgac
    15181 catctgatga gctacgtgta cttctcgaac ttcacccgtc cactgaagtt ggtggtgaac
    15241 tccggaaacg gggctgcggg gcacgtgatt gatgaggtgg agaaacgctt cgcggcggct
    15301 ggggtgccgg taacctttat caaggtgcat caccagccgg atggccattt ccctaacggt
    15361 atcccgaatc cgctgctgcc ggagtgccgc caggataccg ccgacgcggt gcgcgagcat
    15421 caggccgaca tggggattgc ctttgacggc gacttcgatc gctgcttcct gttcgatgac
    15481 gaagcttcgt ttatcgaggg gtattacatt gtcggcctgc tggctgaggc gttcctgcag
    15541 aagcagccgg gagcgaaaat cattcacgac ccgcgcttga cgtggaacac ggtagacatc
    15601 gtgacccgca acggcggcca gccggtgatg tcgaagacgg ggcatgcgtt catcaaggag
    15661 cggatgcgtc aggaagacgc tatctacggc ggggagatga gtgcgcacca ttacttccgc
    15721 gatttcgcct actgcgatag cgggatgatc ccgtggctgc tggtggcgga gctgctgtgt
    15781 ctgaagaaca gctcgctgaa atcgctggtg gcggaccgcc agaaggcgtt ccctgcgtcg
    15841 ggagagatca accgcaagct aagtaatgct gctgaggcga tcgcccgcat ccgggcgcag
    15901 tatgagccgg cggctgcaca catcgacaca acggacggga tcagtattga ataccctgaa
    15961 tggcgcttta acctgcgcac gtctaacacc gagccggtgg tgcgtctgaa cgttgagtcc
    16021 agagctgatg tggcgcttat gaatgaaaaa acgaccgagc tgttacacct gttatgcggg
    16081 gaataaggtg agagatttac taacgacgat ttatcgttat cggggattta tctggagcag
    16141 tgttaaacgt gattttcagg cacgctatca aactagtatg ctgggcgcac tatggctcgt
    16201 tttacaaccg ctctctatga ttctggtcta taccctggtt ttttccgagg tgatgaaggc
    16261 aagaatgccc gataataccg ggtcgtttgc ctatagtatt tatctctgtt ccggggtact
    16321 gacctgggga ttatttactg agatgctgga taaaggtcag agcgtattta ttaacaatgc
    16381 taatctgatc aagaaactca gttttccgaa aatctgtctg ccgatcatcg tgacgttatc
    16441 ggcggtgcta aatttcgcga ttattttcag tctgtttcta atttttatca ttgtcaccgg
    16501 taacttcccc ggctggctct ttctctcggt gataccggtc ctgcttttgc agatcctgtt
    16561 tgccggtggg ctggggatga tccttggtgt catgaacgtc tttttcaggg atgtggggca
    16621 actggttggc gttgcgctgc aattctggtt ttggttcaca cccattgttt atgtattgaa
    16681 ttcattacct gcatgggcaa aaaatctgat gatgtataac ccgatgactc ggataatgca
    16741 atcttatcag tccatcttcg cctatcatct ggcccccaac tggtattcgc tatggccagt
    16801 attggctctc gccattattt tctgcgtcat cggtttcagg atgttccgca agcatgcggc
    16861 ggatatggtg gatgaattat aatgagttat atcagagtaa ataatgtcgg taaggcgtat
    16921 cgccagtatc actcaaagac cgggagactg atcgaatggt tatcccctct gaataccaaa
    16981 cgccataatt tgaaatggat cctccgcgat attaatttcg aagtcgctcc gggcgaggct
    17041 gtcggtatta tcggtatcaa cggtgcaggc aagagtaccc tgcttaaact cataaccggg
    17101 acgtccaggc cgacgactgg agaaattgaa atctccggac gtgtcgctgc attactcgaa
    17161 ttggggatgg ggtttcattc tgatttcact ggtcggcaga atgtttatat gtctgggcaa
    17221 ctgttggggt tatcgtcaga gaaaataact gaactgatgc cgcaaattga agagtttgct
    17281 gagattgggg actatatcga tcaacctgtg cgcgtctact ccagtgggat gcaagttcga
    17341 ttagctttta gtgtagcgac ggctatccgg cctgatgtgc taattatcga tgaggcatta
    17401 tctgttgggg atgcatattt ccagcataaa agctttgagc gtattcgaaa atttcgtcag
    17461 gaagggacca cgctgttgct ggtatcccat gataaacaag cgatccaaag catttgcgac
    17521 cgggccattt tattgaataa aggccaaatt gaaatggaag gtgaacctga agcagtgatg
    17581 gattattaca atgcgcttct ggccgataaa caaaatcagt ccattaaaca agttgagcat
    17641 aatggtaaaa cgcaaactgt ttcaggcact ggtgaggtga ctatctctga ggttcatctt
    17701 ctcgatgaac agggcaatgt gactgaattt gtttcggtag ggcatcgtgt cagcttgcag
    17761 gtcaacgttg aggtcaagga cgatattcct gagcttgttg tcggatatat gattaaggat
    17821 cgacttggac agccgatttt cgggaccaat acgtaccatc tcaatcagac actcacctcc
    17881 ctgaaaaaag gagaaaagcg ttcgttctta ttttctttcg atgcgagatt gggggttggc
    17941 tcctattctg tcgctgtcgc gttgcatact tccagtacgc acctcggcaa aaactatgaa
    18001 tggcgcgatc tggccgtggt attcaacgtc gttaacacgg aacaacaaga gtttgtcggc
    18061 gtgtcctggt tgccgcctga actggagatt tcttaatggg ttcgtcgttt tatcgttcat
    18121 ttgaagaacg acacagaggt tcggttgaag aaatcaagcg ccgcttgagt ttttatttac
    18181 cttttcttgc aggtctgaag gacatttatc ctgatggcgt gattgcggat attggttgcg
    18241 gacgtggcga atggttggag atcctgactg aaaatggcat tgcgaacatc ggcgtcgatc
    18301 tcgatgatgg catgctggcg cgcgccaggg aggccggact gaatgtgcag aaaatggatt
    18361 gtctgcagtt tctgcaaagt caggcggatc agagcctgat agcgttgacc ggttttcata
    18421 ttgctgagca tttgcctttt gaggtcctgc agcagctcgt catgcatacc ctacgggtgc
    18481 tgaaaccagg tggtttgctg atcctcgaaa cgccgaaccc ggagaatgta agcgtcggca
    18541 cctgttcatt ttatatggat ccaacgcata atcatcctct gccaccgcca ctgcttgagt
    18601 ttttacctat tcattatggt tttaacagag caattaccgt tcgtctgcag gaaaaagagg
    18661 ttcttcaatc tccggatgca gccgttaatt tggtcgatgt actcaaaggg gtgagccccg
    18721 actacagcat cattgctcag aaagcagcgc caacagatat tcttgaacgc tttgacaccc
    18781 tgtttaccca gcagtatggt ctgacgctgg atgctctgag caaccgttac gatgcgattt
    18841 tgcgccaaca gttttcgtcc gttgtctcac ggctggagac gttgaaccaa acctatatgc
    18901 aacagataag ccaaatgtca gagactattc agacgttgca aggtgaggtt gacgatctga
    18961 gtcatgtcat cgatcagaac catcagcttc atcagcaaat ggcggattta cataacagtc
    19021 gttcatggcg tattactcaa ccactacgct ggttgtcttt gcaacgtcaa ttattacgtc
    19081 aggaaggggc taaagtgcga gcccgtaggg ctgcgaaaaa aatattgcgc aaagggatgg
    19141 cgctctcgct ggtctttttc catcgttacc ctaagtctaa ggtttatctg tttaaggttc
    19201 tgagaaaaac tggctgctat acattgctac aacgtttgtt ccaacgcgta atgctggtgc
    19261 aatctgacac gatgatgatg cagtccagaa gatatgatgt gggtactgaa gaaatgacaa
    19321 gtcgcgcgat gagtatttat aacgaattaa aaaataaaaa tacggagaaa taacgatgcg
    19381 tattgtcata gatttacaag gcgcacagac ggaaagccgc tttcgtggca tcggtcgtta
    19441 tagtatcgca atcgccagag gcataatcag aaataacagc cggcatgaga ttttcatcgc
    19501 gctatccgcc atgctggatg agtcgattgc ggatattaag gcgcaatttg ccgatctcct
    19561 gccggcagaa aatatagtcg tatggcatgc cgtaggccct gttcgtgcga tggaccaagg
    19621 taatgaatgg cgtcgggaga gcgcagaact gattcgggaa gcgtttcttg aatcattgtg
    19681 tccagatgtc gttttcatta cgagcttgtt tgaaggtcat gtcgacgatg cggctacatc
    19741 ggtacacaaa tttagtcgtc agtataaagt agccgtactg caccacgatc ttatccccct
    19801 cgtgcaggcg gaaacctatc tgcaggacga tgtatacaaa ccctactact tacagaaagt
    19861 tgagtggtta aaaaacgctg accttttgtt gactaactct gcttataccg cacaggaagc
    19921 gatcgagcat ctgcatttac agggcgatca tgtgcagaat attgcagccg cagtcgattc
    19981 tcagttttgt atggcggagg tgacagcgag cgaaaaagag accgtccttg gccattacgg
    20041 tattcagcgc gagttcatgt tgtatgcgcc cggaggattt gactcaagga aaaactttaa
    20101 acggttgatt gaggcctatg ccgggctcag tgatgcctta cgtcgcagtc atcaactggt
    20161 tatcgtcagt aagctttcca tcggtgatcg tcagtatctg gaatcccttg cgtcaggtaa
    20221 tggtttacag caaggcgaac tggtactcac tggttatgtg ccggaagatg agctgatcca
    20281 gctctatcgc ctatgtaagc tgttcatctt tgcttcacta catgaaggtt ttgggttgcc
    20341 ggttctggaa gcaatgtcgt gcggtgcgcc ggtgattggc tcaaatgtca ccagtattcc
    20401 tgaagtcatc ggtaatcctg aggcattatt cgacccgtat tctgtctctt ccatgaggga
    20461 taagatcgcg caatgtttga ctgatgatac cttcctcgcg cgtctgaaag aaatggcgca
    20521 gcagcaagcg cgtaatttct cttgggataa agctgcggtg actgctctgg aggctttcga
    20581 aaagatcgcg gtagaagaca ccggtactgc gcaggttttg cctgaagctt tgattcagaa
    20641 gatccttgct atcacacaag ggcagccaga tgaccgcgat ctgcgcttgt gcgcaacggc
    20701 cattgattac aatctgaaaa cggcagaact ttatcaaatc gacgataaat cgctgaactg
    20761 gcgtgtggaa ggcccattcg atagctcata tagtctggcg ttggtcaacc gcgaatttgc
    20821 ccgggcactc tcagccgatg gtgtagaggt cttattgcat tccactgaag gaccgggtga
    20881 ttttgcccca gatgcctcct ttatggcaca gtcggaaaat agtgatcttc tggcatttta
    20941 taatcaatgt cagacccgca agagtaacga aaagatagat attcttagca gaaatatcta
    21001 tccaccgcgg gttaccaaaa tggatgccaa agtaaaattc cttcattgtt atgcttggga
    21061 agaaacgggc tttccgcaac cgtggatcaa tgaatttaat cgggaacttg acggagtgct
    21121 gtgtacttcg gaacatgttc gtaaaatatt gattgataac ggactgaatg tgcccgcatt
    21181 tgttgttggc aatggctgtg accattggct caatatccca gccgagacga caaaagatgt
    21241 ggatcacgga acattccgtt tcctgcacgt ctcttcttgt ttcccacgca aagggataca
    21301 ggcaatgctt caggcttggg ggaaggcgtt cactcgtcgt gacaatgtta tcttaatcat
    21361 taagactttt aacaatccgc acaatgaaat tgacgcatgg ctggctcagg cccaggctca
    21421 attcatagac tatcccaaag ttgaagtgat caaagaggat atatcagcca ccgagcttaa
    21481 agggctttat gaaagctgtg atgttttggt tgctccaggt tgcgctgaag gctttggttt
    21541 acctattgct gaagcaatgc tgagtgggct accggctatc gtcaccaatt ggagcgggca
    21601 acttgatttt gttaattcac aaaattcatg gctggttgac tatcagttca ctcgggtaaa
    21661 aacgcacttt ggtctgtttt cctcagcctg ggccagtgtg gatattgaca acttaacaga
    21721 tgcattaaaa gcggcagcct caaccgataa atcagtgctg cgtgacatgg ccaatgctgg
    21781 tcgcgagctt cttctgcagc agtttacctg gaaagcggtg gctgatcgtt cttgccaggc
    21841 ggtcaagact ctgcgtgcgc atattgatat tgcacagcat cgggcgcgca ttggctggtt
    21901 gacgacctgg aacacgaaat gtgggatcgc aacctattcc cagcatctgg tggaaagcgc
    21961 acctcatggc gcggatgttg tttttgctcc ccaggtcagc gctggcgatc ttgtgtgtgc
    22021 agacgaagag tttgtacttc gcaactggat tgtaggtaaa gagagcaact atctggaaaa
    22081 cctccagcca cacattgatg ctctgaaact cgatgtcatt gtgatccaat tcaactatgg
    22141 attctttaat catcgagaac tgtcggtgtt tattcgtcgc cagcatgacg ccggtcgttc
    22201 agttgttatg acgatgcact caactgtgga tccgctggaa aaagagccga gctggaattt
    22261 ccgtcttgct gaaatgaaag aggcgctggc actttgcgac cggttgttgg tgcattcgat
    22321 tgccgatatg aaccgcctta aagatttagg cttaactgcg aatgttgctt tattcccgca
    22381 cggtgttatc aactacaccg cagcgagcgt cacacgtcaa cagcagtctt taccgctaat
    22441 tgcgagctat ggcttctgct taccgcataa gggcctgatg gaactagtag aatccgtcca
    22501 tagactcaag caagccggta aaccggttcg tttacgactg gtgaacgcag agtatcctgt
    22561 tggggagtca cgcgatctgg tggcagagct taaagctgct gctcagcggt taggtgttac
    22621 cgatctgatt gagatgcata atgatttcct acctgatgcg gagagtctgc ggttgctttc
    22681 agaagccgat cttctgattt ttgcttatca gaatactggg gagtctgcta gcggggcggt
    22741 acgttatggt atggcgactc aaaaacctgt tgcggtaacg cccctggcga tatttgatga
    22801 tttggacgat gccgtcttta aatttgatgg atgcagcgtc gatgatatca gtcaggggat
    22861 tgaccggatc ctgaattcca tccgtgaaca gaactcttgg gcaaccagga ctcaacaacg
    22921 tgccgatgca tggcgggaac aacatgatta tcaagctgtt tcacgccgtc tggttaatat
    22981 gtgtcaaggc ttagctaaag ctaaatattt taaataaaaa tatctctctt gtattttttg
    23041 cctttgaata caagaggggt tagataatgt gtcatttatt atgaaaatta tttttgctac
    23101 tgagccaatt aaatatccat taacgggcat cggtcggtat tccctggaac tggttaagcg
    23161 gctggcggtc gcccgcgaaa ttgaagaatt aaagctattt cacggtgcgt cgtttatcga
    23221 acagatccct ttggtggaga ataaaagcga taccaaagcc agcaatcatg gtcgtctgtc
    23281 ggcgtttcta cgccgacaga cgctgttgat tgaggcttat cgcttgctgc atccgcggcg
    23341 ccaggcgtgg gcattgcgcg actataagga ttatatctac catggcccca atttttatct
    23401 gccgcataaa ctggaacgcg ccgtgaccac gtttcatgac atatccattt ttacctgccc
    23461 ggaatatcat ccaaaagatc gggttcgcta tatggagaag tccctgcatg agagtctgga
    23521 ttcggcaaag ctgatcctga ccgtttctga tttctcgcgc agtgaaatta tccgcttgtt
    23581 caactatccg gcggagcgga tcgtaaccac caagctagcc tgcagcagtg actatatccc
    23641 acgcagcccg gcagagtgtc tgccggtact gcagaaatat cagctggcgt ggcaggccta
    23701 cgcgctatat atcggcacta tggagccacg taaaaatatc cgaggcctgc tgcatgccta
    23761 tcagctgcta ccgatggaga tccgcatgcg ctatccgcta atccttagcg gctatcgcgg
    23821 ctgggaagac gatgtgctgt ggcagttagt cgagcgcggt actcgggaag gctggatccg
    23881 ttacctcgga tatgttccgg atgaagacct gccgtatctg tacgcagcgg ccagagtctt
    23941 tgtttatccc tccttctacg agggattcgg tttacctatt cttgaagcga tgtcttgcgg
    24001 tgtgccggta gtatgctcca atgtcacctc tttgcctgag gttgttggcg atgccggcct
    24061 cgttgccgat cctaatgata tagacgcgat tagcgcgcaa attttgcaga gcctgcaaga
    24121 tgatagctgg cgggaaatcg ccaccgcgcg cggtcttgct caggcgaaac agttttcgtg
    24181 ggagaactgt gcgacacaga ccattaacgc ctataaatta ctctaagggt gtcagttgag
    24241 agttctacac gtctataaga cttactatcc cgatacctac ggcggtattg agcaggtcat
    24301 ttatcagcta agtcagggct gcgcccgccg gggaatcgca gccgatgttt tcacttttag
    24361 cccggacaaa gatacaggtc ctgtcgctta cgaagatcat cgggtcattt ataataaaca
    24421 gctttttgaa attgcctcca cgccgttttc gctgaaagcg ttaaagcgtt ttaagctgat
    24481 taaagatgac tacgatatca tcaactacca ttttccgttt ccctttatgg atatgctgca
    24541 tctttcggcg cggcctgacg ccaggactgt ggtgacctat cactctgata tagtgaaaca
    24601 aaaacggtta atgaagctgt accagccgct gcaggagcga tttctcagcg gcgtagattg
    24661 catcgttgcc tcgtcgccca attacgtggc ttccagccag accctgaaaa aatatctgga
    24721 taaaacggtg gtgatcccgt ttggtctgga gcagcaggac gtgcagcacg atccgcagag
    24781 ggtcgcgcac tggcgggaaa ctgtcggcga taagttcttt ctcttcgtcg gcactttccg
    24841 ctactacaaa gggctgcata ttctgatgga tgccgctgag cgtagccgac tgccagtggt
    24901 ggttgtaggg ggcgggccgc tggaatcgga agtgcggcgt gaagcgcagc agcgcgggct
    24961 gagcaatgtg atgtttaccg gcatgctcaa cgacgaagat aagtacattc tcttccagct
    25021 ctgccggggc gtggtattcc cctcgcatct gcgctctgag gcgtttggca ttacgttatt
    25081 ggaaggcgca cgctttgcaa ggccgctgat ctcttgcgag atcggtacag gtacctcttt
    25141 cattaaccag gacaaagtga gtggttgcgt gattccgccg aatgatagcc aggcgctggt
    25201 ggaggcgatg aatgagctct ggaataacga ggaaacctcc aaccgctatg gcgaaaactc
    25261 gcgccgtcgt tttgaagaga tgtttactgc cgaccatatg attgacgcct atgtcaatct
    25321 ctacactaca ttgctggaaa gcaaatcctg agagatgcta cccccgccgt tgctgcgggg
    25381 gccaacgcgt taatgccgat tcttcagatt atcaatcact tctccgagat ccagcccctg
    25441 atcctgcaac agcaccagca ggtgatacac caagtcagat gcctcattct tcagctcaaa
    25501 gcggtcattt accgttgcgg ccagtgcggt ttccacgcct tcttcgccca ctttctgcgc
    25561 aatgcgtttg gtgccgctgg catacagttt ggcggtgtag gaggtttccg ggtcggcaga
    25621 tttgcgttcg gcgagcagtt gttccagttg ataaaggaac agccactggt gagcggtgtc
    25681 gccgaagcag ctgctggtgc ctttgtggca ggtcgggccg atgggattcg ccagcaacag
    25741 taacgtgtcg ttgtcgcagt ccggcgcaat atttactacg ttgaggaaat tgcccgacgt
    25801 ttcgcctttg gtccacagtc gctgtttagt gcgcgagaag aaggtgactt tgccgctttc
    25861 gatggttttg tctaaggctt ccgggttcat atagcccagc attaacactt caccggatac
    25921 cgcgtgttgc acaatcaccg gcatcagtcc gtcggttttt tcccagtcca gttcgcgacg
    25981 ttgttgttct gttaacatat cctgatctcc acgccctgtg ttgccaggta cgcttttaat
    26041 tcaccaatat tgattatttg tttgtggaat acggaagctg ccagcgcgcc gtcaacgtcg
    26101 gcatcgcgga aggcttcgag aaagtgttcc atggtgcccg cgccaccgga ggcaattagc
    26161 ggaacgtggc aaacttcacg cacttttttc agttgttcga ggtcgtaacc gttacgcacg
    26221 ccgtcctgat tcatcatgtt gaggacgatt tctccggcac cgcgtttttg cacttcctgt
    26281 acccagtcga gcgtttccca ctgagtgacg cgggtgcggc tttcatcgcc ggtatattga
    26341 ttcacatgat atttaccggt ttcagcgtcg taccaggtat caataccgac cacaatacac
    26401 tgcacgccaa agcgatccgc caggcgagta attaacgtcg ggtccgccag cgcaggggag
    26461 ttgatggaaa ttttatccgc gccaaaggaa agaattttcg cggcatcttc cagagactta
    26521 atc
//